Identification of the IgG1 Induction Factor (Interleukin 4)
نویسندگان
چکیده
منابع مشابه
Identification of the IgG1 Induction Factor (Interleukin 4)
This is an opinion based on the paper “Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter” (1). The mechanism by which B cells can produce classes other than IgM and IgD has interested me since the middle of the 1970s. It was initially not clear that B cells could produce more than one Ig class, whereas we now know that they first produce IgM and Ig...
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15 صفحه اولDifferential regulation of IgG1 and IgE synthesis by interleukin 4
IL-4/B cell stimulatory factor-1 is a T cell-derived lymphokine that has been shown to enhance IgG1 and IgE and to suppress IgG3 and IgG2b secretion by B cells stimulated with bacterial LPS. We show here that the stimulation of IgG1 and IgE secretion in response to rIL-4 is differentially regulated. The dose-response curve for IgG1 production is bimodal with peaks at 100 and 10,000 U/ml. IgE pr...
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We have analyzed requirements for IL-4-induced secretion of IgG1 from anti-Ig-activated B cells. Activated B cell blasts prepared by culture of high density B cells with anti-Ig failed to secrete IgG1 upon subsequent culture with LPS and IL-4. However, IL-4 markedly suppressed IgM secretion in the same cultures. Addition of a mixture of T cell-derived lymphokines or rIL-5 to LPS-stimulated anti...
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Interleukin-4 (IL-4) is a multifunctional cytokine that plays a critical role in apoptosis, differentiation and proliferation. The intensity of IL4 response depends upon binding to its receptor, IL-4R. The therapeutic efficiency of interleukins can be increased by generating structural mutants having greater stability. In the present work, attempts were made to increase the stability of human I...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2014
ISSN: 1664-3224
DOI: 10.3389/fimmu.2014.00628